“This class switch to IgG4 may promote breakthrough infections due to the impairment in Fc-mediated antiviral responses This supports the notion that an increase in IgG4 subclasses could lead to extended viral persistence in case of infection, considering that Fc-mediated effector action is essential for viral elimination. A study by Gazit et al. found that people who received vaccinations and booster shots had a 13-fold greater likelihood of contracting the COVID virus and getting sick. Also, this group saw the greatest number of hospitalizations.”
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